SANTA CLARA, Calif. — Dwight Clark, the receiver who made one of the most memorable plays in NFL history and jump-started the San Francisco 49ers dynasty, died Monday at his home in Montana.

Clark, who had been battling amyotrophic lateral sclerosis (ALS) since he first began feeling weakness in his left hand in September of 2015, was 61 years old.

Clark’s wife, Kelly, shared the news of her husband’s death via his Twitter account.

I’m heartbroken to tell you that today I lost my best friend and husband. He passed peacefully surrounded by many of the people he loved most. I am thankful for all of Dwight’s friends, teammates and 49ers fans who have sent their love during his battle with ALS. Kelly Clark.

— Dwight Clark (@DwightC87) June 4, 2018

“The San Francisco 49ers family has suffered a tremendous loss today with the passing of Dwight Clark,” the team said in a statement. “We extend our condolences and prayers to Dwight’s wife, Kelly, his family, friends and fans, as we join together to mourn the death of one of the most beloved figures in 49ers history. For almost four decades, he served as a charismatic ambassador for our team and the Bay Area. Dwight’s personality and his sense of humor endeared him to everyone he came into contact with, even during his most trying times. The strength, perseverance and grace with which he battled ALS will long serve as an inspiration to so many. Dwight will always carry a special place in our hearts and his legacy will live on as we continue to battle this terrible disease.”

Clark first disclosed his diagnosis in March 2017 on former 49ers owner Ed DeBartolo Jr.’s website, but said in that statement that he began feeling weak in 2015. After what he called months of tests and treatment, Clark was diagnosed with ALS, which is also known as Lou Gehrig’s disease.

In the time since his diagnosis, Clark said he had lost strength in both hands, his midsection, lower back and his right leg while also losing significant weight. DeBartolo helped Clark and his family relocate in March to be near him in Whitefish, Montana. In April, DeBartolo hosted a group of about 30 friends and former 49ers to visit Clark at his Montana ranch.

“It was beautiful because we got to see him smile,” said former teammate Roger Craig, who said he almost fainted when he heard the news of Clark’s death.

“That’s all I wanted, to see him smiling. We cried, we all got a taste of Dwight, all we wanted to do is see him smile the whole time we all were there and he smiled the whole time. He made us feel good and I know he felt good knowing he had all those teammates there to support him.”

Garrison Hearst, who was among the former teammates who visited Clark in Montana, tweeted that “We lost a great one.”

?????? Rest In Peace!!! We lost a great one!!! Love you brother!!! pic.twitter.com/FT6lE4qAGD

— Garrison Hearst (@garrisonhearst5) June 4, 2018

In a statement, DeBartolo said that he “lost my little brother and one of my best friends.”

“I cannot put into words how special Dwight was to me and to everyone his life touched,” DeBartolo said. “He was an amazing husband, father, grandfather, brother and a great friend and teammate. He showed tremendous courage and dignity in his battle with ALS and we hope there will soon be a cure for this horrendous disease.

“I will always remember Dwight the way he was — larger than life, handsome, charismatic and the only one who could pull off wearing a fur coat at our Super Bowl parade. He was responsible for one of the most iconic plays in NFL history that began our run of Super Bowl championships, but to me, he will always be an extension of my family. I love him and will miss him terribly. Our hearts and prayers are with his wife Kelly, his children and the entire Clark family.”

The 49ers held “Dwight Clark Day” last season at an Oct. 22 game against the Dallas Cowboys.

In what would be his final appearance in front of such a large group of 49ers fans, Clark addressed the crowd, ownership, his family and more than 40 teammates from a Levi’s Stadium suite. That day, he said he simply wanted one more chance to be around the team he loved.

“When Keena Turner [San Francisco’s vice president of football affairs] asked me what I wanted to do, whether raise money or have some kind of function, I said I just want to see my teammates,” Clark said that day. “And the 49ers heard that and flew all these players in so I could see them one more time.”

In honor of Clark, the 49ers gave away T-shirts with images of “The Catch,” the leaping grab Clark made in the back of the end zone to beat the Cowboys in the 1981 NFC Championship Game, imprinted over his No. 87. Famous sportscaster Vin Scully narrated a video tribute to Clark that was played on the scoreboard, and Hall of Fame quarterback Joe Montana introduced Clark.

“Dwight was a vibrant charismatic soul!! Jennifer and I are heartbroken over his passing,” Montana wrote in a Twitter post Monday night. “While we knew it was inevitably coming, it came way [too] soon! We are grateful for the decades of love and friendship we shared.”

“The Catch” spurred the Niners to their first Super Bowl victory and was the unofficial beginning of a dynasty that would see San Francisco win four world championships in the 1980s as well as make eight playoff appearances in 10 seasons.

Known as “Sprint Right Option,” the play became one of the most iconic in league and franchise history. On the play, Montana took the snap and rolled to his right before floating a pass in Clark’s direction. Clark timed his leap and his reach just right and hauled in the pass by his fingertips before landing safely in the right corner of the north end zone. The Niners went on to a 28-27 victory and would go on to win Super Bowl XVI against the Cincinnati Bengals.

Thirteen quarterbacks came off the board in the 2018 NFL draft, including five in the first round alone. How have they looked so far?

NFL Nation reporters offer early progress reports on their performances at rookie minicamps and organized team activities.

Round 1, No. 1 overall

The draft’s first overall pick is starting over. Mayfield spent a fair amount of time in rookie camp practicing taking the snap from center. In the first OTA practice open to the media, Mayfield threw three interceptions. In the second, his reps seemed to be reduced by a few. None of this means he can’t play; it shows that he’s learning the fundamentals and basics of playing in the NFL. — Pat McManamon

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Round 1, No. 3 overall

The key word: progress. After a rough start in OTAs, Darnold settled down in the second week, perhaps not coincidentally when he started getting reps with the first-team line. His arm talent is obvious. For Darnold, the biggest challenge is knowing where to throw the ball and getting it out on time. He’s getting more reps on a daily basis than vets Josh McCown and Teddy Bridgewater, and that should benefit him come training camp. He’ll get a shot to be the Week 1 starter, but it would take a spectacular preseason to nail down the job. — Rich Cimini

Round 1, No. 7 overall

Allen has practiced exclusively with the third team through the first two weeks of OTAs, behind AJ McCarron and Nathan Peterman on the depth chart. It has been a mixed bag so far for Allen, who was inaccurate on his first pass and later telegraphed an interception to cornerback Breon Borders during the two-minute drill in Thursday’s practice. Coaches gave Allen another shot at the drill, and he marched downfield and lofted an accurate fade pattern to wide receiver Cam Phillips for a touchdown. Allen’s off-the-charts arm strength has been evident in the velocity of the passes he has thrown; the accuracy seems to be a work in progress. — Mike Rodak

Round 1, No. 10 overall

So far, the scouting report on Rosen has been dead-on. He was hyped as the most NFL-ready quarterback in this year’s draft because of the combination of his intelligence and skill. From what he has shown during the limited practices open to the media, he’s both smart and talented. His arm has been live, especially on deep passes. It’s clear he can think through a play rather quickly and efficiently. From what his offensive linemen have said about him so far, he’s been displaying a maturity and confidence in the huddle that has been well received. — Josh Weinfuss

Round 1, No. 32 overall

Jackson remains a work in progress. He’s accurate in the middle of the field and shows good touch on deep passes. But he’s inconsistent when throwing outside the numbers. His passes tend to sail when targeting receivers along the sideline. What jumps out is Jackson’s speed. When he gets into the open field, he makes jaw-dropping cuts to elude defenders. The Ravens will get Jackson on the field immediately because of his explosiveness, but he isn’t close to competing with Joe Flacco for the starting quarterback job. — Jamison Hensley

Round 2, No. 76 overall

Rudolph has shown off his arm strength, has a good touch on the deep ball and seems to be adjusting well to the offensive scheme. In OTAs, Rudolph hasn’t made any major mistakes but has played it relatively safe and overthrew a few receivers. The under-center exchanges were a problem early in rookie camp. Overall, Rudolph is about what the Steelers expected: an intriguing, down-the-road option. — Jeremy Fowler

Round 4, No. 108 overall

Lauletta was up and down at rookie minicamp and served as the fourth-string quarterback at OTA No. 1 behind Eli Manning, Davis Webb and Alex Tanney. There’s going to be a steep learning curve for Lauletta making the jump from Richmond to the NFL. His arm isn’t spectacular (as advertised), so everything else has to be perfect for him to succeed. But you can tell from talking to him that this is a smart young man who understands the game of football. — Jordan Raanan

The seventh-round pick from Florida International was the standout of the team’s rookie minicamp. Pete Carroll remarked afterward how McGough showed nice arm strength and accuracy in addition to the mobility the Seahawks had already seen plenty of on his college tape. The usual qualifiers apply. It was only a three-day minicamp with no veterans and no shoulder pads (those have been the only practices open to the media so far). McGough still has a lot to prove to unseat Austin Davis as Russell Wilson’s backup, but he’s off to a nice start. — Brady Henderson

KANSAS CITY, Mo. — Patrick Mahomes’ social calendar was full during May in town. He was spotted at a Jason Aldean concert, threw out the first pitch at a Royals game and wore jorts and a sleeveless baseball jersey to a NASCAR race.

It’s not that Mahomes didn’t indulge in some Kansas City events last year, when he was a Chiefs rookie and the backup quarterback to Alex Smith. But seemingly every one of his outings is now celebrated on social media, and there’s little doubt that he’s taking over the town as he becomes the starter.

Mahomes tried last season to blend in with the surroundings. He walked precisely the delicate balance between being the first signal-caller picked in the first round by the Chiefs in 34 years and being the supportive No. 2 quarterback. Much has been made of how Smith was the perfect mentor for Mahomes, but it’s just as true that having Mahomes capably deflect attention away from himself benefited Smith in his final season in Kansas City.

Now the starter, Mahomes is still liberal with the compliments for his teammates and his new hometown. But he’s no longer deferential. The trade of Smith to Washington was hardly completed when Mahomes began bugging his teammates for throwing sessions, long before offseason practice started.

Kansas City Fashion Icons. ??? pic.twitter.com/OsE6llLV4g

— Sluggerrr (@Sluggerrr) May 19, 2018

“He just took control out there on the first day,” tight end Travis Kelce said. “That’s the biggest thing is seeing that he does have control of the room at such a young age, knowing this is his first rodeo in the NFL. He’s not shy about taking the lead and that’s huge. It makes it easier on all of us to see the direction of where this can go and it’s easy to follow that.

“It’s exciting and it’s something I think we’re going to have to do together knowing Pat’s situation, him coming into a role with a lot of scrutiny at the quarterback position. It’s definitely going to be a team effort to try to get him rolling.”

Mahomes didn’t come to Kansas City with much experience at being the backup. He was a reserve for part of his true freshman year at Texas Tech, but he moved into the starting lineup before that season was finished and stayed there for his final two seasons with the Red Raiders.

Still, he knew enough to largely stay in his cocoon as a rookie, to be seen but seldom heard.

“That’s the same for every rookie,” Mahomes said. “Every rookie, you come in and you just try to work hard and kind of keep your head down, I guess you would say, and just try to prove to the team that you’re trying to do whatever is best for the team.

“As you gain some of that respect, as you go further in your career, you start talking more and people can really respect what you’re saying because they know you’re in the best interest of your team.”

Mahomes’ background helped him in this regard. He has been around pro sports most of his life. His father, Pat, pitched for 11 seasons with six teams in Major League Baseball.

“He grew up in that environment and understood sort of intrinsically a whole lot of what passes for etiquette in team sports,” said Mahomes’ agent, Leigh Steinberg.

Steinberg is a longtime agent who has represented many of the NFL’s top quarterbacks. He said that keeping a low profile as a rookie was part of the plan for Mahomes.

“I talked through with him the process of maturation and process of integration that many of our quarterbacks have went through, whether it was Troy Aikman or Steve Young or Warren Moon,” Steinberg said. “We talked about how the first year the goal was to integrate into the team, and the only way to do that is to pay deference to the incumbent veterans and try not to go into the situation with a high profile.

“We intentionally didn’t do endorsements that would run in the Kansas City area even though they were offered. We didn’t want him to be on billboards and everything when he wasn’t even playing.”

The plan will change now that Mahomes is the starter.

He needs to take command of the locker room, one that already features established voices like those of Kelce and safety Eric Berry. That can be tricky for a young player, but Mahomes didn’t seem daunted by the task.

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The wider field won’t impede Johnny Manziel in the Canadian Football League. Neither will the 20-second play clock, the 12-man defensive looks, the punts on third down nor the pre-snap motion. It’s all of it, all at once, all while Manziel is in a hurry to master this league so he can move on to the next.

Most American quarterbacks need a year or more to adjust and thrive in the CFL. But if Manziel is to return to the NFL when his two-year contract expires, he must speed up the traditional timetable and put extended periods of high-end play on tape right away. He can start measuring his progress Friday night when he debuts in the Hamilton Tiger-Cats’ preseason opener, scheduled to kick off on ESPN+ at 7:30 p.m. ET.

“Some guys come up here and they can have success right away,” said Edmonton Eskimos quarterback Mike Reilly, the CFL’s Most Outstanding Player in 2017. “But it takes some time to really understand what’s happening. It’s hard. It’s hard to be successful here right out of the gates. That’s definitely going to be a challenge.”

To be fair, most quarterbacks who migrate north don’t have Manziel’s athletic skills and pedigree. Reilly, for example, went undrafted in 2009 out of Central Washington. He was released by four NFL teams over 18 months before moving to the CFL, and only after spending two seasons on the bench did he get a chance to start in 2013.

Current Tiger-Cats starter Jeremiah Masoli spent three seasons on the bench after signing in 2013 out of Mississippi. Hamilton coach June Jones has said he is committed to Masoli as the starter, but some of Jones’ other public comments — such as when he said last winter that Manziel would be the “best player to ever play up here” — suggest he is eager to get Manziel on the field.

“I think Johnny will come fast because we’re not going to change things from here on,” Jones said this week. “He has the whole offense in, and he’s been running it on the field. Now, does he know what he’s doing with it yet? No. But because we’re repping it all with him now, he’s going to come faster than what is typical.”

Manziel has acknowledged the steep learning curve but told reporters this week that he has “a pretty good grasp on almost everything that we’re doing.” He said he has played Jones’ run ‘n’ shoot scheme “a million” times on EA Sports’ “NCAA Football,” and Jones said his approach in many ways mirrors the three- and four-receiver sets Manziel utilized at Texas A&M.

“I looked at every pass he threw in the NFL out of a four-wide, a three-wide, out of an empty set,” Jones said, “and he threw the ball just like he did in college out of those. What the NFL did to him is put him in something he had never been in before. Never in high school, never in college, he had never run what he was asked to do. But when he was asked to do the things he had done, which is what he’ll be asked to do here, he looked like an All-Pro.”

Indeed, 97 percent of Manziel’s throws in college came out of sets with at least three receivers on the field, according to ESPN Stats & Information research. That number dropped to 70 percent over two seasons with the Cleveland Browns.

But Jones’ enthusiasm for his scheme, and Manziel’s fit in it, glosses over the more fundamental challenges of this transition. People I spoke with this week reinforced what others said during a trip to Hamilton in 2016: American visions of Manziel mirroring the success of Doug Flutie, another Heisman Trophy winner who moved north to find success, are outdated. Rather than scramble madly from wide sideline to sideline, successful CFL quarterbacks must now throw accurately and efficiently from the pocket above all else.

If anything, the league’s three-down structure discourages quarterbacks from taking chances on unscripted runs or off-schedule throws. Lost yardage on first down, or even a minimal gain, leads to the NFL equivalent of third-and-long, effectively quashing drives. Historically, according to league data, CFL teams convert first downs on second-and-10 or longer between 12 and 14 percent of the time. In 2017, they converted 35.9 percent on plays of second-and-7 or longer.

“A lot of guys start out up here by extending the play and trying to make things happen downfield,” Reilly said. “That’s how you can make up for a lack of seasoning. But that’s only going to take you so far. Defensive coordinators aren’t stupid. They can take that away and keep you in the pocket. You have to be able to go through your progressions and understand what the defenses are and where the advantages are.”

While he appreciates Manziel’s mobility, Jones said that — if anything — it’s less important in the CFL than in the NFL.

“Accuracy is the most important thing,” Jones said. “A lot of times, people think it’s guys with mobility and that kind of stuff, but to me, it’s always been accuracy with the football. You look at the guys that are at the top of the league with a chance at the Grey Cup, they’re not runners. They’re accurate passers. If you want to win it all, you have to have a guy that can see a guy and hit him.”

Can Manziel be that player? Jones thinks so. And you might be surprised to know that in his final college season, Manziel led all qualified players in completion percentage on throws from the pocket (73.5). But first, Manziel will have to master a set of rules and alternate structures that have tripped up many American quarterbacks north of the border.

During a phone conversation this week, Reilly detailed five differences quarterbacks have to adjust to while transitioning to the CFL. Here are those five differences in his words:

1. Twelve players on each side

Reilly’s breakdown: “Having 12 guys on offense, that sounds great. OK, I get an extra receiver. But the additional guy defensively allows defensive coordinators to draw up so many different coverages that you don’t even see in the States. There are essentially three safeties. When you get an extra guy out there, they can bring pressures that they can’t bring in the States. They can drop into certain zone coverages and things like that.

“You have your typical zones that you see in the NFL or in American football: Cover 2, Cover 3, Cover 4 and some combination. You may get two to one side, four to the other side, two-man, man, things like that. But the way that the defensive coordinators here can create different schemes in different zones, it’s not the same as in American football. The windows aren’t the same. How you read different coverages is not the same.”

2. Only three downs

Reilly’s breakdown: “You have to be extremely efficient with every single play that you have. We don’t have that extra down. We can’t just go in there and pound the ball up the middle and run the ball and try to get yards. If we’re going to run the ball on first down, we have to get 4 or 5 yards for it to feel successful. Likewise when you’re throwing the ball on first down. You need yards.”

3. Wider (about 12 yards) and longer (10) fields

Reilly’s breakdown: “When we’re on the left hash and we’re throwing the ball to the right sideline, you’re talking almost the width of an American football field. And so the windows that you have to be comfortable throwing in are different, understanding that the ball is going to be in the air longer and that the defensive backs have more time to break. That cushion that you might have in American football where a guy is open and you throw it, here that cushion and that window is different.

“You see it all the time with young guys that come up here and try to throw a corner route to the field side and the ball skips 10 yards short of the wide receiver. They’re like, ‘Wow, I’ve got to recalibrate and readjust.’ Everybody generally has a strong-enough arm to do it, but understanding what makes a guy actually open enough to throw the ball requires a different thought process.”

4. Twenty-second play clock and two timeouts

Reilly’s breakdown: “If you’re [at the line of scrimmage] and things are a little bit confusing, in American football, it’s the second quarter, you can burn a timeout. There’s no problem with that. Here in Canada, we get two timeouts for the game, we only have one challenge per game and we have to have a timeout to use a challenge. So if it’s the second quarter and we burn a timeout, we’ve just limited ourselves in what we can do potentially in crunch time if we need to throw a challenge flag.

“You can’t just snap the ball and throw it out of bounds, because it’s second-and-10 and you’ve pretty much wasted that drive. So that’s a big change as a quarterback, is knowing where the play clock is at all times and being able to get your guys in and out of the huddle at a fast tempo.

“You have to be able to assess what the defense is doing in a very short period of time, and if you’re trying to change out of the play with a pressure check, the operation has to be very, very quick. So I think everything in terms of mentally what you have to do pre-snap, it is all much more sudden.”

5. Pre-snap motions

Reilly’s breakdown: “That changes everything, too. It is an advantage to be able to have three or four receivers motioning from one side of the field to the other, and motioning toward the line of scrimmage to get a running start against the defense. That’s all great. But what you have to understand, too, is that the defense is also going to be moving around and making adjustments based on your motion. So when you’re at the line of scrimmage and you send your receivers in motion, you’ve got about two or three seconds before you’re going to snap the ball, and what the defense was showing you before the motions versus after the motions is going to be completely different.